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llulko,
That is a great question. According to the research more sets or reps really would not help, since it only takes one-two sets to maximum that stimulates protein synthesis maximally.
I think the best case would be to specialize the muscle groups a little more. For example instead of doing big mover exercises like a squat, do leg extension and leg curl, and calf raise for the leg.
That way you optimize the ability of each muscle group being stimulated maximally. Whereas with a big mover exercise like a pull or squat you may have one part of the leg tire more quickly.
So know the argument is…
For someone that can only workout once a day, wouldn’t they benefit most from doing 3-4 heavy sets of compound exercises?
In this case they will be activating every muscle group while getting the benefits of lean muscle mass, fat loss, increased intensity, and increased metabolism..
I would think this protocol is better then doing smaller muscle groups..